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pentobarbital will lessen the extent or impact of dienogest/estradiol valerate by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Gals shouldn't decide on estradiol valerate/dienogest as their contraceptive although utilizing potent CYP3A4 inducers because of probable lessen in contraceptive efficacy.So in case you don’t g